5 edition of Potassium Channels: Basic Function and Therapeutic Aspects found in the catalog.
Written in English
|Contributions||Thomas J. Colatsky (Editor)|
|The Physical Object|
|Number of Pages||362|
Rheumatoid arthritis is a painful inflammatory disorder. Patients seek relief mostly with analgesics and anti-inflammatory drugs which are rife with life-threatening side effects. Alterations in the body’s potassium (K) status may be one such factor. K along with sodium is critical to cellular homeostasis and the electrophysiology of nerve by: 3. Start studying Pharmacology Summer CCC - EXAM 4 (Final) - Book Questions. Learn vocabulary, terms, and more with flashcards, games, and other study tools.
The vessel wall is an intricate structure composed of three layers: the intima (consisting of endothelial cells), media (consisting of smooth muscle cells and elastic fibers), and externa (consisting of the extracellular matrix scaffold). The homeostasis of the vasculature depends on the consistent function of each layer. In the vascular system, potassium channels are well known to regulate Author: Yan-Rong Zhu, Xiao-Xin Jiang, Peng Ye, Shao-liang Chen, Dai-Min Zhang. Voltage gated potassium channels have been extensively studied in relation to cancer. In this review, we will focus on the role of two potassium channels, Ether à-go-go (Eag), Human ether à-go-go related gene (HERG), in cancer and their potential therapeutic utility in the treatment of cancer. Eag and HERG are expressed in cancers of various organs and have been implicated in cell cycle Cited by:
The human body requires at least milligrams of potassium daily to support key functions. Among its many uses, potassium helps to regulate . BBA - Molecular and Cell Biology of Lipids, ISSN , 06/, Volume , Issue 6, pp. -
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Potassium channels: basic function and therapeutic aspects. Proceedings of the 29th annual A.N. Richards Symposium. Valley Forge, Pennsylvania, Maypotassium channels basic function and therapeutic aspects progress in clinical and biological research volume Posted By Erle Stanley Gardner Media TEXT ID de26 Online PDF Ebook Epub Library is tightly associated with a number of brain diseases such as alzheimers disease epilepsy fragile x syndrome fxs parkinsons disease chronic pain tinnitus and potassium.
Get this from a library. Potassium channels: basic function and therapeutic aspects: proceedings of the 29th Annual A.N. Richards Symposium held at Valley Forge, Pennsylvania, May[Thomas J Colatsky;]. This book is the first to focus on potassium ion channels and covers the recent remarkable progress made in research on these proteins.
Many diseases are caused by the abnormalities of potassium ion channels. They include diabetes mellitus, life-threatening hereditary cardiac arrhythmia, epilepsy, neural degeneration, and renal Edition: 1.
Online shopping for Books from a great selection of Biological Sciences, Nature & Ecology, Mathematics, Physics, Earth Sciences, Chemistry & more at everyday low prices. As the number of drugs acting on calcium and potassium channels grows, there is a need for a continuous reappraisal of the cellular machinery controlling them.
The present volume provides an update on the basic knowledge, the molecular targets of the two channels, and the importance the drugs that. In: Colatsky TJ (ed) Potassium channels: basic function and therapeutic aspects. Liss, New York, pp – Google Scholar Southerton JS, Taylor SG, Weston AH () Comparison of the effects of BRL and of acetylcholine-liberated EDRF on rat isolated by: As the number of drugs acting on calcium and potassium channels grows, there is a need for a continuous reappraisal of the cellular machinery controlling them.
The present volume provides an update on the basic knowledge, the molecular targets of the two channels, and the importance the drugs that bind them have as pharmacological tools and therapeutic agents. Potassium Channels: Molecular Defects, Diseases, and Therapeutic Opportunities Article Literature Review in Pharmacological Reviews 52(4) January with Reads.
Basic Neurochemistry: Molecular, Cellular and Medical Aspects, a comprehensive text on neurochemistry, is now updated and revised in its Seventh well-established text has been recognized worldwide as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for graduate and postgraduate students and instructors in the 4/5(1).
The potassium channel superfamily presents a rich source of targets for therapeutic intervention. Indeed, the development of specific potassium channel modulators could lead to the effective. Author(s): Colatsky,Thomas J; A.N. Richards Symposium,(29th: Valley Forge, Pa.) Title(s): Potassium channels: basic function and therapeutic aspects.
ATP-sensitive potassium (KATP) channels are weak, inward rectifiers that couple metabolic status to cell membrane electrical activity, thus modulating many cellular functions Cited by: KCNQ-encoded potassium channels: Features, Functions and Pharmacology. Reflections and future scanning.
KCNQ-encoded Kv7 channels hold a special place in many people’s hearts because they have so many facets. Firstly, they are major regulators of cellular function in the heart, brain, smooth muscle, skeletal muscle and epithelia.
Title: Potassium Channel Openers: The Case of BK Channel Activators VOLUME: 3 ISSUE: 4 Author(s):A. Nardi, V.
Calderone and S.- P. Olesen Affiliation:Dept of Chemistry,NeuroSearch, Pederstrup Ballerup, DK, Denmark. Keywords:Potassium channels, BK-channels, Maxi-K channels, drug design, BK channel activator, synthesis Abstract: Large-conductance calcium-activated potassium channels.
Pharmacological Control of Calcium and Potassium Homeostasis (Medical Science Symposia Series) [T. Godfraind] on *FREE* shipping on qualifying offers. As the number of drugs acting on calcium and potassium channels grows, there is a need for a continuous reappraisal of the cellular machinery controlling them.4/5(1).
Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals is a unique reference that provides a complete overview of the non-vitamin micronutrients, including calcium, copper, iodine, iron, magnesium, manganese, molybdenum, phosphorus, potassium, selenium, sodium, and zinc.
In addition, the book covers the nutritional and toxicological properties of nonessential minerals. SK channels (small conductance calcium-activated potassium channels) are a subfamily of Ca 2+-activated K + channels.
They are so called because of their small single channel conductance in the order of 10 pS. SK channels are a type of ion channel allowing potassium cations to cross the cell membrane and are activated (opened) by an increase in the concentration of intracellular calcium InterPro: IPR Potassium channels represent a large and heterogenous family of ion channels, and generally function to dampen neuronal excitation by inducing membrane hyperpolarization.
Hence, they represent a natural target for AED development. Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore. Their functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of ions across the cell membrane, controlling the flow of ions across secretory and epithelial cells, and regulating cell volume.
Viral delivery of Kir channels to striatal astrocytes restored Kir function, normalized extracellular K+, ameliorated aspects of MSN Cited by: Brazilian Journal of Biology Its is possible that potassium channels might be involved in the relaxation induced by EBDA since it was isolate substances openers BK Ca (MacManus et al., ).
Further studies are necessary to test this possibility. Potassium channel: basic function and therapeutic aspects. Wiley-liss, New York, pp. The mutations seen in BFNE are thought to cause a reduction in the current amplitude through the potassium channels, which leads to a transient susceptibility to seizures.
The more severe phenotypes of epileptic encephalopathy have been reported to be associated with loss of function as well as with dominant negative and gain of function effects.